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dc.rights.licenseopenen_US
dc.contributor.authorROUBAUD BAUDRON, C.
dc.contributor.authorLEGERON, R.
dc.contributor.authorOLLIVIER, J.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBONNET, Fabrice
dc.contributor.authorGREIB, C.
dc.contributor.authorGUERVILLE, F.
dc.contributor.authorCAZANAVE, C.
dc.contributor.authorKOBEH, D.
dc.contributor.authorCRESSOT, V.
dc.contributor.authorMONEGER, N.
dc.contributor.authorVIDEAU, M. N.
dc.contributor.authorTHIEL, E.
dc.contributor.authorFOUCAUD, C.
dc.contributor.authorLAFARGUE, A.
dc.contributor.authorDE THEZY, A.
dc.contributor.authorDURRIEU, J.
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorBOURDEL MARCHASSON, Isabelle
dc.contributor.authorPINGANAUD, G.
dc.contributor.authorBREILH, D.
dc.date.accessioned2020-07-10T11:55:27Z
dc.date.available2020-07-10T11:55:27Z
dc.date.issued2019-12-01
dc.identifier.issn0305-7453en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10407
dc.description.abstractEnBACKGROUND: Antibiotic administration by subcutaneous (SC) injection is common practice in French geriatric wards as an alternative to the intravenous (IV) route, but few pharmacokinetic/pharmacodynamic data are available. Ertapenem is useful for the treatment of infections with ESBL-producing enterobacteria. OBJECTIVES: To report and compare ertapenem pharmacokinetic data between IV and SC routes in older persons. METHODS: Patients >65 years of age receiving ertapenem (1 g once daily) for at least 48 h (IV or SC, steady-state) were prospectively enrolled. Total ertapenem concentrations [residual (C0), IV peak (C0.5) and SC peak (C2.5)] were determined by UV HPLC. Individual-predicted AUC0-24 values were calculated and population pharmacokinetic analyses were performed. Using the final model, a Monte Carlo simulation involving 10 000 patients evaluated the influence of SC or IV administration on the PTA. Tolerance to ertapenem and recovery were also monitored. ClinicalTrials.gov identifier: NCT02505386. RESULTS: Ten (mean +/- SD age=87+/-7 years) and 16 (age=88+/-5 years) patients were included in the IV and SC groups, respectively. The mean C0 and C2.5 values were not significantly different between the IV and SC groups (C0=12+/-5.9 versus 12+/-7.4 mg/L, P=0.97; C2.5=97+/-42 versus 67+/-41 mg/L, P=0.99). The mean C0.5 was higher in the IV group compared with the SC group (C0.5=184+/-90 versus 51+/-66 mg/L, P=0.001). The mean individual AUCs (1126.92+/-334.99 mg.h/L for IV versus 1005.3+/-266.0 mg.h/L for SC, P=0.38) and PTAs were not significantly different between groups. No severe antibiotic-related adverse effects were noted. CONCLUSIONS: SC administration of ertapenem is an alternative to IV administration in older patients.
dc.language.isoENen_US
dc.subject.enMORPH3Eus
dc.title.enIs the subcutaneous route an alternative for administering ertapenem to older patients? PHACINERTA study
dc.title.alternativeJ Antimicrob Chemotheren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/jac/dkz385
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31730164en_US
bordeaux.journalThe Journal of antimicrobial chemotherapyen_US
bordeaux.page3546-3554en_US
bordeaux.volume74en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue12en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03162359
hal.version1
hal.date.transferred2021-03-08T13:40:41Z
hal.exporttrue
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