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Congenital Chagas Disease in the Ecuadorian Amazon: Maternal Screening at Delivery and Evaluation of Risk Factors Associated with Vector Exposure

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRESTREPO ZAMBRANO, Marion
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorROUSET, Faustine
dc.contributor.authorCARRASCO, O. F.
dc.contributor.authorECHEVERRIA MURILLO, D.
dc.contributor.authorCOSTALES, J. A.
dc.contributor.authorBRENIERE, S. F.
dc.date.accessioned2020-07-10T09:57:25Z
dc.date.available2020-07-10T09:57:25Z
dc.date.issued2019-12
dc.identifier.issn1476-1645 (Electronic) 0002-9637 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10400
dc.description.abstractEnCongenital infection with Trypanosoma cruzi remains a major route for Chagas disease transmission in endemic and non-endemic regions. We evaluated an intervention strategy aimed to detect congenital Chagas disease cases at a major hospital in the Ecuadorian Amazon via cord blood analysis at the time of delivery. All women giving birth at the hospital during the study period (191) were invited to participate. Among them, two (1.0%) did not adjust to the inclusion criteria and four (2.1%) declined to participate in the study, showing the intervention had good acceptability among the mothers. It was possible to obtain cord blood samples during 146 of the deliveries, and only one woman was found to be seropositive, without evidence of transmission to the newborn at delivery or 8 months later. In addition, sociodemographic and economic characterization of the study population revealed that few women had previous knowledge about Chagas disease (16.1%) whereas more than half (62.5%) recognized the vector. Recognizing the vector and having seen it indoors were associated with women from rural families, involved in agriculture, and hunting in the forest. Interestingly, most women (87.3%) reported having easy access to Ecuador's national health system, suggesting serological screening during prenatal visits would be of value in this province. With a proper prenatal screening system in place, cord blood screening would allow for timely detection of T. cruzi infection in newborns from both seropositive women and the minority (2.1%) of women who do not comply with prenatal care visits.
dc.language.isoENen_US
dc.subject.enISPED
dc.title.enCongenital Chagas Disease in the Ecuadorian Amazon: Maternal Screening at Delivery and Evaluation of Risk Factors Associated with Vector Exposure
dc.title.alternativeAm J Trop Med Hygen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.4269/ajtmh.19-0340en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31595866en_US
bordeaux.journalThe American Journal of Tropical Medicine and Hygieneen_US
bordeaux.page1350-1358en_US
bordeaux.volume101en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue6en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03162652
hal.version1
hal.date.transferred2021-03-08T14:55:18Z
hal.exporttrue
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