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Photoacoustic imaging of tumor targeting with riboflavin-functionalized theranostic nanocarriers

hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorBEZTSINNA, Nataliia
dc.contributor.authorTSVETKOVA, Yoanna
dc.contributor.authorJOSE, Jithin
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorRHOURRI-FRIH, Boutayna
dc.contributor.authorAL RAWASHDEH, Wa'el
dc.contributor.authorLAMMERS, Twan
dc.contributor.authorKIESSLING, Fabian
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorBERQUE BESTEL, Isabelle
dc.date.accessioned2020-07-09T14:17:13Z
dc.date.available2020-07-09T14:17:13Z
dc.date.issued2017
dc.identifier.issn1178-2013
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10359
dc.description.abstractEnPhotoacoustic imaging is an emerging method in the molecular imaging field, providing high spatiotemporal resolution and sufficient imaging depths for many clinical applications. Therefore, the aim of this study was to use photoacoustic imaging as a tool to evaluate a riboflavin (RF)-based targeted nanoplatform. RF is internalized by the cells through a specific pathway, and its derivatives were recently shown as promising tumor-targeting vectors for the drug delivery systems. Here, the RF amphiphile synthesized from a PEGylated phospholipid was successfully inserted into a long-circulating liposome formulation labeled with the clinically approved photoacoustic contrast agent - indocyanine green (ICG). The obtained liposomes had a diameter of 124 nm (polydispersity index = 0.17) and had a negative zeta potential of -26 mV. Studies in biological phantoms indicated a stable and concentration-dependent photoacoustic signal (Vevo (R) LAZR) of the ICG-containing RF-functionalized liposomes. In A431 cells, a high uptake of RF-functionalized liposomes was found and could be blocked competitively. First, studies in mice revealed similar to 3 times higher photoacoustic signal in subcutaneous A431 tumor xenografts (P<0.05) after injection of RF-functionalized liposomes compared to control particles. In this context, the application of a spectral unmixing protocol confirmed the initial quantitative data and improved the localization of liposomes in the tumor. In conclusion, the synthesized RF amphiphile leads to efficient liposomal tumor targeting and can be favorably detected by photoacoustic imaging with a perspective of theranostic applications.
dc.title.enPhotoacoustic imaging of tumor targeting with riboflavin-functionalized theranostic nanocarriers
dc.typeArticle de revue
dc.identifier.doi10.2147/ijn.s125192
dc.subject.halChimie/Matériaux
bordeaux.journalInternational Journal of Nanomedicine
bordeaux.page3813-3825
bordeaux.volume12
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248*
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248)
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=International%20Journal%20of%20Nanomedicine&amp;rft.date=2017&amp;rft.volume=12&amp;rft.spage=3813-3825&amp;rft.epage=3813-3825&amp;rft.eissn=1178-2013&amp;rft.issn=1178-2013&amp;rft.au=BEZTSINNA,%20Nataliia&amp;TSVETKOVA,%20Yoanna&amp;JOSE,%20Jithin&amp;RHOURRI-FRIH,%20Boutayna&amp;AL%20RAWASHDEH,%20Wa'el&amp;rft.genre=article


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