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EV-Associated MMP9 in High-Grade Serous Ovarian Cancer Is Preferentially Localized to Annexin V-Binding EVs

dc.contributor.authorREINER, Agnes T.
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorTAN, Sisareuth
dc.contributor.authorAGREITER, Christiane
dc.contributor.authorAUER, Katharina
dc.contributor.authorBACHMAYR-HEYDA, Anna
dc.contributor.authorAUST, Stefanie
dc.contributor.authorPECHA, Nina
dc.contributor.authorMANDORFER, Mattias
dc.contributor.authorPILS, Dietmar
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorBRISSON, Alain
dc.contributor.authorZEILLINGER, Robert
dc.contributor.authorLIM, Sai Kiang
dc.date.accessioned2020-07-09T14:17:11Z
dc.date.available2020-07-09T14:17:11Z
dc.date.issued2017
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10356
dc.description.abstractEnHigh-grade serous ovarian cancer (HGSOC) is the most aggressive type of ovarian cancer and is responsible for most deaths caused by gynecological cancers. Numerous candidate biomarkers were identified for this disease in the last decades, but most were not sensitive or specific enough for clinical applications. Hence, new biomarkers for HGSOC are urgently required. This study aimed to identify new markers by isolating different extracellular vesicle (EV) types from the ascites of ovarian cancer patients according to their affinities for lipid-binding proteins and analyzing their protein cargo. This approach circumvents the low signal-to-noise ratio when using biological fluids for biomarker discovery and the issue of contamination by large non-EV complexes. We isolated and analyzed three distinct EV populations from the ascites of patients with ovarian cancer or cirrhosis and observed that Annexin V-binding EVs have higher levels of matrix metalloproteinase 9 in malignant compared to portal-hypertensive ascites. As this protein was not detected in other EV populations, this study validates our approach of using different EV types for optimal biomarker discovery. Furthermore, MMP9 in Annexin V-binding EVs could be a HGSOC biomarker with enhanced specificity, because its identification requires detection of two distinct components, that is, lipid and protein.
dc.title.enEV-Associated MMP9 in High-Grade Serous Ovarian Cancer Is Preferentially Localized to Annexin V-Binding EVs
dc.typeArticle de revue
dc.identifier.doi10.1155/2017/9653194
dc.subject.halChimie/Matériaux
bordeaux.journalDisease Markers
bordeaux.page9653194-9653194
bordeaux.volume2017
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248*
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248)
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Disease%20Markers&rft.date=2017&rft.volume=2017&rft.spage=9653194-9653194&rft.epage=9653194-9653194&rft.au=REINER,%20Agnes%20T.&TAN,%20Sisareuth&AGREITER,%20Christiane&AUER,%20Katharina&BACHMAYR-HEYDA,%20Anna&rft.genre=article


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