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The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors

hal.structure.identifierLaboratoire Angiogenèse et Micro-environnement des Cancers [LAMC]
dc.contributor.authorBOYE, Kevin
hal.structure.identifierLaboratoire Angiogenèse et Micro-environnement des Cancers [LAMC]
dc.contributor.authorPUJOL, Nadege
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorALVES, Isabel
dc.contributor.authorCHEN, Y. P.
hal.structure.identifierLaboratoire Angiogenèse et Micro-environnement des Cancers [LAMC]
dc.contributor.authorDAUBON, Thomas
dc.contributor.authorLEE, Y. Z.
dc.contributor.authorDEDIEU, S.
hal.structure.identifierLaboratoire Angiogenèse et Micro-environnement des Cancers [LAMC]
dc.contributor.authorCONSTANTIN, Marion
dc.contributor.authorBELLO, L.
dc.contributor.authorROSSI, M.
dc.contributor.authorBJERKVIG, R.
dc.contributor.authorSUE, S. C.
hal.structure.identifierLaboratoire Angiogenèse et Micro-environnement des Cancers [LAMC]
dc.contributor.authorBIKFALVI, Andreas
hal.structure.identifierLaboratoire Angiogenèse et Micro-environnement des Cancers [LAMC]
dc.contributor.authorBILLOTTET, Clotilde
dc.date.accessioned2020-07-09T14:17:09Z
dc.date.available2020-07-09T14:17:09Z
dc.date.issued2017-11
dc.identifier.issn2041-1723
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10352
dc.description.abstractEnCXCR3 plays important roles in angiogenesis, inflammation, and cancer. However, the precise mechanism of regulation and activity in tumors is not well known. We focused on CXCR3-A conformation and on the mechanisms controlling its activity and trafficking and investigated the role of CXCR3/LRP1 cross talk in tumor cell invasion. Here we report that agonist stimulation induces an anisotropic response with conformational changes of CXCR3-A along its longitudinal axis. CXCR3-A is internalized via clathrin-coated vesicles and recycled by retrograde trafficking. We demonstrate that CXCR3-A interacts with LRP1. Silencing of LRP1 leads to an increase in the magnitude of ligand-induced conformational change with CXCR3A focalized at the cell membrane, leading to a sustained receptor activity and an increase in tumor cell migration. This was validated in patient-derived glioma cells and patient samples. Our study defines LRP1 as a regulator of CXCR3, which may have important consequences for tumor biology.
dc.title.enThe role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors
dc.typeArticle de revue
dc.identifier.doi10.1038/s41467-017-01686-y
dc.subject.halChimie/Matériaux
bordeaux.journalNature Communications
bordeaux.volume8
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248*
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248)
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Communications&rft.date=2017-11&rft.volume=8&rft.eissn=2041-1723&rft.issn=2041-1723&rft.au=BOYE,%20Kevin&PUJOL,%20Nadege&ALVES,%20Isabel&CHEN,%20Y.%20P.&DAUBON,%20Thomas&rft.genre=article


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