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Chemistry, bioactivity and biosynthesis of cyanobacterial alkylresorcinols

dc.rights.licenseopenen_US
dc.contributor.authorMARTINS, Teresa P.
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorROUGER, Caroline
IDREF: 158011724
dc.contributor.authorGLASSER, Nathaniel R.
dc.contributor.authorFREITAS, Sara
dc.contributor.authorDE FRAISSINETTE, Nelly B.
dc.contributor.authorBALSKUS, Emily P.
dc.contributor.authorTASDEMIR, Deniz
dc.contributor.authorLEÃO, Pedro N.
dc.date.accessioned2020-07-08T20:21:41Z
dc.date.available2020-07-08T20:21:41Z
dc.date.issued2019
dc.identifier.issn0265-0568en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10220
dc.description.abstractEnCovering: up to 2019 Alkylresorcinols are amphiphilic metabolites, well-known for their diverse biological activities, produced by both prokaryotes and eukaryotes. A few classes of alkylresorcinol scaffolds have been reported from the photoautotrophic cyanobacteria, ranging from the relatively simple hierridins to the more intricate cylindrocyclophanes. Recently, it has emerged that cyanobacteria employ two different biosynthetic pathways to produce unique alkylresorcinol scaffolds. However, these convergent pathways intersect by sharing biosynthetic elements which lead to common structural motifs. To obtain a broader view of the biochemical diversity of these compounds in cyanobacteria, we comprehensively cover the isolation, structure, biological activity and biosynthesis of their mono- and dialkylresorcinols. Moreover, we provide an overview of the diversity and distribution of alkylresorcinol-generating biosynthetic gene clusters in this phylum and highlight opportunities for discovery of novel alkylresorcinol scaffolds. Because some of these molecules have inspired notable syntheses, different approaches used to build these molecules in the laboratory are showcased.
dc.language.isoENen_US
dc.title.enChemistry, bioactivity and biosynthesis of cyanobacterial alkylresorcinols
dc.title.alternativeNat. prod. rep.en_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1039/c8np00080hen_US
dc.subject.halSciences du Vivant [q-bio]/Biologie végétaleen_US
dc.identifier.pubmed30702733en_US
bordeaux.journalNatural Product Reportsen_US
bordeaux.page1437-1461en_US
bordeaux.volume36en_US
bordeaux.hal.laboratoriesOenologie - EA 4577en_US
bordeaux.issue10en_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Natural%20Product%20Reports&rft.date=2019&rft.volume=36&rft.issue=10&rft.spage=1437-1461&rft.epage=1437-1461&rft.eissn=0265-0568&rft.issn=0265-0568&rft.au=MARTINS,%20Teresa%20P.&ROUGER,%20Caroline&GLASSER,%20Nathaniel%20R.&FREITAS,%20Sara&DE%20FRAISSINETTE,%20Nelly%20B.&rft.genre=article


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