https://oskar-bordeaux.fr/handle/20.500.12278/78816 2026-04-09T15:46:14Z https://oskar-bordeaux.fr/handle/20.500.12278/207796 Blood vessel and osteocyte networks concurrently rearrange during bone maturation and decline during aging in the femur of male mice PALMIER, Mathilde; MAÎTRE, Marlène; DOAT, Hélène; LESTÉ-LASSERRE, Thierry; BOIZIAU, Claudine; MAUREL, Delphine B 2025-08-22T00:00:00Z https://oskar-bordeaux.fr/handle/20.500.12278/207795 Development of flexible nanoporous gold electrodes for the detection of glucose DEMURTAS, Denise; ALVAREZ-MALMAGRO, Julia; RATHORE, Arvind; MANDAL, Tanushree; QUINTERO-JAIME, Andrés Felipe; BELOCHAPKINE, Serguei; LIELPETERE, Anna; JAYAKUMAR, Kavita; LEECH, Dónal; SCHUHMANN, Wolfgang; MANO, Nicolas; BOIZIAU, Claudine; MAGNER, Edmond 2025-10-01T00:00:00Z https://oskar-bordeaux.fr/handle/20.500.12278/206679 GALVEZ, Paul; D’INCAU, Emmanuel; TAILLARD, Jacques; P. MARTIN, Vincent; CARRA, Maria Clotilde; FENELON, Mathilde; CHUY, Virginie; COELHO, Julien; PHILIP, Pierre; MICOULAUD-FRANCHI, Jean-Arthur 2025-04-22T00:00:00Z https://oskar-bordeaux.fr/handle/20.500.12278/206152 CHUY, Virginie; MATYJASIK, Pierre; DEVILLARD, Raphael; KEROUREDAN, Olivia 2025-01-30T00:00:00Z https://oskar-bordeaux.fr/handle/20.500.12278/206037 LAHOUATI, Marin; BROUSSE, Xavier; BIENTZ, Léa; CHADEFAUX, Grégoire; DUBOIS, Véronique; CAZANAVE, Charles; XUEREB, Fabien 2025-03-31T00:00:00Z https://oskar-bordeaux.fr/handle/20.500.12278/205740 Development of flexible nanoporous gold electrodes for the detection of glucose DEMURTAS, Denise; ALVAREZ-MALMAGRO, Julia; RATHORE, Arvind; MANDAL, Tanushree; QUINTERO-JAIME, Andrés Felipe; BELOCHAPKINE, Serguei; LIELPETERE, Anna; JAYAKUMAR, Kavita; LEECH, Dónal; SCHUHMANN, Wolfgang; MANO, Nicolas; BOIZIAU, Claudine; MAGNER, Edmond The development of implantable glucose sensors is of significant interest in the management of diabetes. This work focuses on developing an implantable, biocompatible nanoporous gold electrode prototype based on Kapton® for the subcutaneous detection of glucose. The electrodes were first modified with a layer containing glucose oxidase and Os(2,2′-bipyridine) 2 Cl⋅PVI (Os(bpy) 2 Cl PVI). An additional polymeric layer containing poly (2-methacryloyloxyethyl phosphorylcholine-co-glycidyl methacrylate) was then added to reduce biofouling and foreign body reaction effects. The modified electrode had a V MAX of 211 ± 13 μA cm -2 and a K Mapp of 6.1 ± 0.8 mM in pseudo physiological conditions, with a linear detection range from 1 to 4 mM and a sensitivity of 28.6 ± 2.1 μA cm -2 mM -1 . In artificial plasma, the response of the sensor was saturated at 3 mM, with a V MAX of 113 ± 10 μA cm -2 and a K Mapp of 2.1 ± 0.4 mM with a linear detection range from 1 to 2.5 mM and a sensitivity of 14.6 ± 3.3 μA cm -2 mM -1 . Mechanical stress testing demonstrated that there was a 40 % reduction of the redox polymer coverage after 320 deformation events, however the catalytic activity was still detectable after 160 events. Minimal cytotoxicity effects of the electrodes were observed. When subcutaneously implanted the electrodes showed fairly good mechanical stability after one week and detachment of the metallic layer on some electrodes after 21 days, probably due to electrode bending. A limited foreign body reaction was observed. These results indicated that the electrodes could be implanted for a period of up to 1 week. 2025-10-01T00:00:00Z https://oskar-bordeaux.fr/handle/20.500.12278/205737 Effects of Sterilization on Cellobiose Dehydrogenase and Glucose Oxidase Based Glucose Biosensors BENNETT, Richard; RATHORE, Arvind; GOUNEL, Sébastien; LIELPETERE, Anna; REICHHART, Thomas M.B.; JAYAKUMAR, Kavita; LUDWIG, Roland; FELICE, Alfons K.G.; LEECH, Dónal; SCHUHMANN, Wolfgang; MOUNT, Andrew; MANO, Nicolas; BOIZIAU, Claudine AbstractResearch on implantable glucose biosensors is driven by the need for innovative medical devices for continuous glucose monitoring in patients with diabetes mellitus. However, biosensor sterilization is a step that is widely omitted during the process of innovation. To compare the effects of gamma irradiation and chemical treatment with ethylene oxide (carbon microarray electrodes are fabricated, functionalized with glucose oxidizing enzymes (cellobiose dehydrogenase CDH or glucose oxidase GOx), and coated with a specifically designed zwitterionic polymer prior to the sterilization step. Cyclic voltammetry in the presence of 100 mm glucose of the biosensors before and after sterilization shows that gamma irradiation with a low radiation rate (25 kGy, 260 Gy h−1) does not induce a sensor performance loss, unlike the EtO treatment. In addition, no cytotoxic by‐products are released after gamma sterilization. Based on these results obtained with both glucose oxidizing enzymes (CDH and GOx), gamma irradiation of the glucose biosensors with a low dose rate is preferable to exposure to EtO for biosensor terminal sterilization. 2024-09-18T00:00:00Z https://oskar-bordeaux.fr/handle/20.500.12278/205730 DE PINHO, Natalia Alencar; PREZELIN-REYDIT, Mathilde; HARAMBAT, Jerome; COUCHOUD, Cécile; GLAUDET, Florence; COMBE, Christian; RONDEAU, Virginie; LEFFONDRÉ, Karen 2024-05-31T00:00:00Z https://oskar-bordeaux.fr/handle/20.500.12278/205729 Inferior alveolar nerve repositioning surgical techniques and outcomes – A systematic review ALLAVÉNA, Julie; NICOT, Romain; MAJOUFRE, Claire; SCHLUND, Matthias 2024-02-01T00:00:00Z https://oskar-bordeaux.fr/handle/20.500.12278/205728 BARRY, Florent; SCHLUND, Matthias; FERRI, Joël 2024-06-01T00:00:00Z